Dataset Information

Tailored axillary surgery in patients with clinically node-positive breast cancer: Pre-planned feasibility substudy of TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101).

ABSTRACT:

Aim

We developed tailored axillary surgery (TAS) to reduce the axillary tumor volume in patients with clinically node-positive breast cancer to the point where radiotherapy can control it. The aim of this study was to quantify the extent of tumor load reduction achieved by TAS.

Methods

International multicenter prospective study embedded in a randomized trial. TAS is a novel pragmatic concept for axillary surgery de-escalation that combines palpation-guided removal of suspicious nodes with the sentinel procedure and, optionally, imaging-guided localization. Pre-specified study endpoints quantified surgical extent and reduction of tumor load.

Results

A total of 296 patients were included at 28 sites in four European countries, 125 (42.2%) of whom underwent neoadjuvant chemotherapy (NACT) and 71 (24.0%) achieved nodal pathologic complete response. Axillary metastases were detectable only by imaging in 145 (49.0%) patients. They were palpable in 151 (51.0%) patients, of whom 63 underwent NACT and 21 had residual palpable disease after NACT. TAS removed the biopsied and clipped node in 279 (94.3%) patients. In 225 patients with nodal disease at the time of surgery, TAS removed a median of five (IQR 3-7) nodes, two (IQR 1-4) of which were positive. Of these 225 patients, 100 underwent ALND after TAS, which removed a median of 14 (IQR 10-17) additional nodes and revealed additional positive nodes in 70/100 (70%) of patients. False-negative rate of TAS in patients who underwent subsequent ALND was 2.6%.

Conclusions

TAS selectively reduced the tumor load in the axilla and remained much less radical than ALND.

SUBMITTER: Weber WP

PROVIDER: S-EPMC8463904 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Publications

Tailored axillary surgery in patients with clinically node-positive breast cancer: Pre-planned feasibility substudy of TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101).

Weber Walter P WP Matrai Zoltan Z Hayoz Stefanie S Tausch Christoph C Henke Guido G Zwahlen Daniel R DR Gruber Günther G Zimmermann Frank F Seiler Stefanie S Maddox Charlotte C Ruhstaller Thomas T Muenst Simone S Ackerknecht Markus M Kuemmel Sherko S Bjelic-Radisic Vesna V Kurzeder Christian C Újhelyi Mihály M Vrieling Conny C Satler Rok R Meyer Inna I Becciolini Charles C Bucher Susanne S Simonson Colin C Fehr Peter M PM Gabriel Natalie N Maráz Robert R Sarlos Dimitri D Dedes Konstantin J KJ Leo Cornelia C Berclaz Gilles G Dubsky Peter P Exner Ruth R Fansa Hisham H Hager Christopher C Reisenberger Klaus K Singer Christian F CF Reitsamer Roland R Reinisch Mattea M Winkler Jelena J Lam Giang Thanh GT Fehr Mathias K MK Naydina Tatiana T Kohlik Magdalena M Clerc Karine K Ostapenko Valerijus V Fitzal Florian F Nussbaumer Rahel R Maggi Nadia N Schulz Alexandra A Markellou Pagona P Lelièvre Loïc L Egle Daniel D Heil Jörg J Knauer Michael M

Breast (Edinburgh, Scotland) 20210908

<h4>Aim</h4>We developed tailored axillary surgery (TAS) to reduce the axillary tumor volume in patients with clinically node-positive breast cancer to the point where radiotherapy can control it. The aim of this study was to quantify the extent of tumor load reduction achieved by TAS.<h4>Methods</h4>International multicenter prospective study embedded in a randomized trial. TAS is a novel pragmatic concept for axillary surgery de-escalation that combines palpation-guided removal of suspicious n ...[more]

PMID: 34555676

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Dataset Information

Tailored axillary surgery in patients with clinically node-positive breast cancer: Pre-planned feasibility substudy of TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101).

Aim

Methods

Results

Conclusions

Publications

Tailored axillary surgery in patients with clinically node-positive breast cancer: Pre-planned feasibility substudy of TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101).

Similar Datasets

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