Diagnosis and prognosis models for hepatocellular carcinoma patient's management based on tumor mutation burden.

ABSTRACT:

Introduction

The development and prognosis of HCC involve complex molecular mechanisms, which affect the effectiveness of its treatment strategies. Tumor mutational burden (TMB) is related to the efficacy of immunotherapy, but the prognostic role of TMB-related genes in HCC has not yet been determined clearly.

Objectives

In this study, we identified TMB-specific genes with good prognostic value to build diagnostic and prognostic models and provide guidance for the treatment of HCC patients.

Methods

Weighted gene co-expression network analysis (WGCNA) was applied to identify the TMB-specific genes. And LASSO method and Cox regression were used in establishing the prognostic model.

Results

The prognostic model based on SMG5 and MRPL9 showed patients with higher p

SUBMITTER: Tang B 

PROVIDER: S-EPMC8463909 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature