Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.

ABSTRACT:

Introduction

Some epidemiological studies have revealed that vitamin D (VD) deficiency is closely linked with the prevalence of obesity, however, the role of VD in energy homeostasis is yet to be investigated, especially in central nervous system. Given that VD negatively regulates renin in adipose tissue, we hypothesized that central VD might play a potential role in energy homeostasis.

Objectives

The present study aims to investigate the potential role of VD in energy homeostasis in the CNS and elaborate its underlying mechanisms.

Methods

This study was conducted in Cyp27b1 ^-/- mice, VD-treated and wild-type mice. After the intraventricular injection of renin or its inhibitors, the changes of renin-angiotensin system (RAS) and its down-stream pathw

SUBMITTER: Su H 

PROVIDER: S-EPMC8463910 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature