PIK3CB is involved in metastasis through the regulation of cell adhesion to collagen I in pancreatic cancer.

ABSTRACT:

Introduction

Pancreatic adenocarcinoma (PAAD) is an aggressive malignancy, with a major mortality resulting from the rapid progression of metastasis. Unfortunately, no effective treatment strategy has been developed for PAAD metastasis to date. Thus, unraveling the mechanisms involved in PAAD metastatic phenotype may facilitate the treatment for PAAD patients.

Objectives

PIK3CB is an oncogene implicated in cancer development and progression but less is known about whether PIK3CB participates in PAAD metastasis. Therefore, the objective of this study is to explore the mechanism(s) of PIK3CB in PAAD metastasis.

Methods

In our study, we examined the PIK3CB expression pattern using bioinformatic analysis and clinical material derived from patients with PAAD. Subseq

SUBMITTER: Qu J 

PROVIDER: S-EPMC8463925 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature