Magnitude of the Placebo Response Across Treatment Modalities Used for Treatment-Resistant Depression in Adults: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

The placebo effect in depression clinical trials is a substantial factor associated with failure to establish efficacy of novel and repurposed treatments. However, the magnitude of the placebo effect and whether it differs across treatment modalities in treatment-resistant depression (TRD) is unclear.

Objective

To examine the magnitude of the placebo effect in patients with TRD across different treatment modalities and its possible moderators.

Data sources

Searches were conducted on MEDLINE, Web of Science, and PsychInfo from inception to June 21, 2021.

Study selection

Randomized clinical trials (RCTs) were included if they recruited patients with TRD and randomized them to a placebo or sham arm and a pharmacotherapy, brain stimulation, or psychother

SUBMITTER: Jones BDM 

PROVIDER: S-EPMC8463940 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature