Separation of ctDNA by superparamagnetic bead particles in microfluidic platform for early cancer detection.

ABSTRACT:

Introduction

Conventional biopsy, based on extraction from a tumor of a solid tissue specimen requiring needles, endoscopic devices, excision or surgery, is at risk of infection, internal bleeding or prolonged recovery. A non-invasive liquid biopsy is one of the greatest axiomatic consequences of the identification of circulating tumor DNA (ctDNA) as a replaceable surgical tumor bioQpsy technique. Most of the literature studies thus far presented ctDNA detection at almost final stage III or IV of cancer, where the treatment option or cancer management is nearly impossible for diagnosis.

Objective

Hence, this paper aims to present a simulation study of extraction and separation of ctDNA from the blood plasma of cancer patients of stage I and II by superparamagnetic (SPM) bead

SUBMITTER: Balakrishnan SG 

PROVIDER: S-EPMC8463959 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature