Innate tumor-targeted nanozyme overcoming tumor hypoxia for cancer theranostic use.

ABSTRACT:

Introduction

Hypoxic tumor microenvironment (TME) is the major contributor to cancer metastasis, resistance to chemotherapy, and recurrence of tumors. So far, no approved treatment has been available to overcome tumor hypoxia.

Objectives

The present study aimed to relieve tumor hypoxia via a nanozyme theranostic nanomaterial as well as providing magnetic resonance imaging (MRI)-guided therapy.

Methods

Manganese dioxide (MnO₂) was used for its intrinsic enzymatic activity co-loaded with the anti-cancer drug Doxorubicin (Dox) within the recombinant heavy-chain apoferritin cavity to form MnO₂-Dox@HFn. Following the synthesis of the nanomaterial, different characterizations were performed as well as its nanozyme-like ability. This nanoplatform recogn

SUBMITTER: Veroniaina H 

PROVIDER: S-EPMC8463960 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature