Deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure.

ABSTRACT: The onset and mechanisms underlying neurodegenerative diseases remain uncertain. The main features of neurodegenerative diseases have been related with cellular and molecular events like neuronal loss, mitochondrial dysfunction and aberrant accumulation of misfolded proteins or peptides in specific areas of the brain. The most prevalent neurodegenerative diseases belonging to age-related pathologies are Alzheimer's disease, Huntington's disease, Parkinson's disease and amyotrophic lateral sclerosis. Interestingly, mitochondrial dysfunction has been observed to occur during the early onset of several neuropathological events associated to neurodegenerative diseases. The master regulator of mitochondrial quality control and energetic metabolism is the transcriptional coactivator peroxisome p

SUBMITTER: Panes JD 

PROVIDER: S-EPMC8463972 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature