SPaRTAN, a computational framework for linking cell-surface receptors to transcriptional regulators.

ABSTRACT: The identity and functions of specialized cell types are dependent on the complex interplay between signaling and transcriptional networks. Recently single-cell technologies have been developed that enable simultaneous quantitative analysis of cell-surface receptor expression with transcriptional states. To date, these datasets have not been used to systematically develop cell-context-specific maps of the interface between signaling and transcriptional regulators orchestrating cellular identity and function. We present SPaRTAN (Single-cell Proteomic and RNA based Transcription factor Activity Network), a computational method to link cell-surface receptors to transcription factors (TFs) by exploiting cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) datasets with cis

SUBMITTER: Ma X 

PROVIDER: S-EPMC8464045 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature