Leveraging three-dimensional chromatin architecture for effective reconstruction of enhancer-target gene regulatory interactions.

ABSTRACT: A growing amount of evidence in literature suggests that germline sequence variants and somatic mutations in non-coding distal regulatory elements may be crucial for defining disease risk and prognostic stratification of patients, in genetic disorders as well as in cancer. Their functional interpretation is challenging because genome-wide enhancer-target gene (ETG) pairing is an open problem in genomics. The solutions proposed so far do not account for the hierarchy of structural domains which define chromatin three-dimensional (3D) architecture. Here we introduce a change of perspective based on the definition of multi-scale structural chromatin domains, integrated in a statistical framework to define ETG pairs. In this work (i) we develop a computational and statistical framework to reco

SUBMITTER: Salviato E 

PROVIDER: S-EPMC8464068 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature