Serum creatinine as a biomarker for dystrophinopathy: a cross-sectional and longitudinal study.

ABSTRACT:

Background

Dystrophinopathy, a common neuromuscular disorder, includes Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). Many researches are currently ongoing to develop curative approaches, which results in an urgent need for biomarkers of disease progression and treatment response. This study investigated whether the serum creatinine (SCRN) level can be used as a biomarker of disease progression in dystrophinopathy.

Methods

We enrolled 377 male patients with dystrophinopathy and 520 male non-dystrophinopathy controls in a cross-sectional study. From this cohort, 113 follow-up patients were enrolled in a longitudinal study. Patients' demographic information, motor function, muscle fatty infiltration, and muscle dystrophin levels were evaluated. We inves

SUBMITTER: Wang L 

PROVIDER: S-EPMC8464115 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature