Effect of supercritical carbon dioxide fluid extract from Chrysanthemum indicum Linne on bleomycin-induced pulmonary fibrosis.

ABSTRACT:

Background

As a prevalent type of cryptogenic fibrotic disease with high mortality, idiopathic pulmonary fibrosis (IPF) still lacks effective therapeutic drugs. The compounds extracted from buds and flowers of Chrysanthemum indicum Linné with supercritical-carbon dioxide fluid (CI_SCFE) has been confirmed to have antioxidant, anti-inflammatory, and lung-protective effects. This paper aimed to clarify whether CI_SCFE could treat IPF induced by bleomycin (BLM) and elucidate the related mechanisms.

Methods

Rats (Sprague-Dawley, male) were separated into the following groups: normal, model, pirfenidone (50 mg/kg), CI_SCFE-L, -M, and -H (240, 360, and 480 mg/kg/d, i.g., respectively, for 4 weeks). Rats were given BLM (5 mg/kg) via intratracheal insta

SUBMITTER: Nie J 

PROVIDER: S-EPMC8464116 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature