Infective mastitis due to bovine-associated Streptococcus dysgalactiae contributes to clinical persistent presentation in a murine mastitis model.

ABSTRACT:

Background

Mastitis caused by Streptococcus dysgalactiae (GCS) is a major pathology of dairy cows. The mechanisms by which GCS intramammary infection is established and maintained involve not only bacterial adherence and invasion but also modulation of the cytokines and TLR immune response.

Objectives

The study aimed to evaluate characteristics of persistent infection of GCS collected from bovine mastitis milk in a murine mastitis model whose mammary structure is similar to that of dairy cows; dairy cow mastitis can be well simulated by using mice as models. HLJ2019 was tested for its ability to persistently infected mice by intramammary inoculation.

Methods

As antibiotics tested, establish an intramammary infection model in murine, histopathology analyses, relative e

SUBMITTER: An R 

PROVIDER: S-EPMC8464300 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature