HNRNPC Promotes Proliferation, Metastasis and Predicts Prognosis in Prostate Cancer.

ABSTRACT:

Introduction

The incidence of prostate cancer remains high worldwide, while exploring new therapeutic targets for prostate cancer is essential. Heterogeneous nuclear ribonucleoproteins have been proved to regulate tumorigeneses in various cancers. This study aimed to explore the role of HNRNPC in prostate cancer progression.

Methods

HNRNPC expression and its correlation with clinical features and immune infiltration were analyzed by bioinformatics analysis. The effects of HNRNPC on prostate cell proliferation, migration, and invasion were accessed by EdU, colony formation, transwell, and wound-healing assays.

Results

The expression level of HNRNPC was significantly increased in prostate cancer tissues and was correlated with the T stage, N stage, Gleason score, PSA le

SUBMITTER: Wang S 

PROVIDER: S-EPMC8464311 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature