Prenatal opioid administration induces shared alterations to the maternal and offspring gut microbiome: A preliminary analysis.

ABSTRACT: Background While many studies have described the impact of prenatal opioid exposure on development, possible mechanisms for how opioids exert developmental impairments remain elusive. Emerging evidence indicates disruptions in the maternal gut microbiome can alter offspring development; however, no studies to date have examined the impact of maternal opioid treatment on maternal-offspring microbiome dysbiosis. Methods A mouse model of prenatal methadone exposure (PME) was employed to assess the impact of maternal opioid treatment on the microbiome of methadone-treated dams (MD) and their offspring. Fecal samples were collected from dams (n = 8 per treatment), one male and one female offspring per dam (n = 8 offspring per sex per treatment) for 16S rRNA sequencing. Results Methadone treatme

SUBMITTER: Grecco GG 

PROVIDER: S-EPMC8464518 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature