The relationship of frequency of cocaine use to substance and psychiatric disorders in the U.S. general population.

ABSTRACT:

Background

In clinical trials of pharmacotherapy for substance use, abstinence is the primary endpoint accepted by regulatory agencies. However, this endpoint could be overly restrictive, impeding efforts to identify effective medications for cocaine use disorder. To examine non-abstinent gradations in cocaine use as potential indicators of improvement, we investigated the relationship of frequency of cocaine use to clinical correlates in national survey data.

Methods

Lifetime cocaine users (n = 2501) were interviewed in the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) in 2001-2002 and re-interviewed in 2004-2005. Adjusted odds ratios (aORs) indicated associations between heaviest frequency of cocaine use and use of other substances, DSM-IV subs

SUBMITTER: Aharonovich E 

PROVIDER: S-EPMC8464522 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature