Assessment of transient dopamine responses to smoked cannabis.

ABSTRACT:

Background

Dopaminergic mechanisms that may underlie cannabis' reinforcing effects are not well elucidated in humans. This positron emission tomography (PET) imaging study used the dopamine D_2/3 receptor antagonist [¹¹C]raclopride and kinetic modelling testing for transient changes in radiotracer uptake to assess the striatal dopamine response to smoked cannabis in a preliminary sample.

Methods

PET emission data were acquired from regular cannabis users (n = 14; 7 M/7 F; 19-32 years old) over 90 min immediately after [¹¹C]raclopride administration (584 ± 95 MBq) as bolus followed by constant infusion (K_bol = 105 min). Participants smoked a cannabis cigarette, using a paced puff protocol, 35 min after scan start. Plasma concentratio

SUBMITTER: Calakos KC 

PROVIDER: S-EPMC8464527 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature