Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo.

ABSTRACT:

Introduction

Vitiligo pathogenesis is complicated, and several possibilities were suggested. However, it is well-known that the metabolism of pigments plays a significant role in the pathogenicity of the disease.

Objectives

We explored the role of amino acids in vitiligo using targeted metabolomics.

Methods

The amino acid profile was studied in plasma using liquid chromatography. First, 22 amino acids were derivatized and precisely determined. Next, the concentrations of the amino acids and the molar ratios were calculated in 31 patients and 34 healthy individuals.

Results

The differential concentrations of amino acids were analyzed and eight amino acids, i.e., cysteine, arginine, lysine, ornithine, proline, glutamic acid, histidine, and glycine were observed d

SUBMITTER: Marzabani R 

PROVIDER: S-EPMC8464575 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature