Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1.

ABSTRACT: Dopaminergic (DA) neurons in the arcuate nucleus (ARC) of the hypothalamus play essential roles in the secretion of prolactin and the regulation of energy homeostasis. However, the gene regulatory network responsible for the development of the DA neurons remains poorly understood. Here we report that the transcription factor special AT-rich binding protein 2 (Satb2) is required for the development of ARC DA neurons. Satb2 is expressed in a large proportion of DA neurons without colocalization with proopiomelanocortin (POMC), orexigenic agouti-related peptide (AgRP), neuropeptide-Y (NPY), somatostatin (Sst), growth hormone-releasing hormone (GHRH), or galanin in the ARC. Nestin-Cre;Satb2^flox/flox (Satb2 CKO) mice show a reduced number of ARC DA neurons with unchanged numbers of t

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC8464595 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature