Primer for Development of Guidelines for Helicobacter pylori Therapy Using Antimicrobial Stewardship.

ABSTRACT: We provide a primer to assist in the difficult transition of Helicobacter pylori therapy guidelines to those that adhere to the principles of antimicrobial stewardship. This transition will entail abandonment of many of the principles that heretofore formed the basis of treatment guidelines and recommendations. The goals of antimicrobial stewardship include optimization of the use of antibiotics while reducing antimicrobial resistance. The critical outcome measure is absolute cure rate which largely restricts comparative trials to those which reliably produce high cure rates (eg, ∼95%). Therapies that fail to achieve at least a 90% cure rate should be abandoned as unacceptable. Because only optimized therapies should be prescribed, guidance on the principles and practices of optimization w

SUBMITTER: Graham DY 

PROVIDER: S-EPMC8464630 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature