Recent Chemical and Pharmacological Developments on 14-Oxygenated-N-methylmorphinan-6-ones.

ABSTRACT: Adequate pain management, particularly chronic pain, remains a major challenge associated with modern-day medicine. Current pharmacotherapy offers unsatisfactory long-term solutions due to serious side effects related to the chronic administration of analgesic drugs. Morphine and structurally related derivatives (e.g., oxycodone, oxymorphone, buprenorphine) are highly effective opioid analgesics, mediating their effects via the activation of opioid receptors, with the mu-opioid receptor subtype as the primary molecular target. However, they also cause addiction and overdose deaths, which has led to a global opioid crisis in the last decades. Therefore, research efforts are needed to overcome the limitations of present pain therapies with the aim to improve treatment efficacy and to reduce

SUBMITTER: Spetea M 

PROVIDER: S-EPMC8464912 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature