Sweetpotato Leaves Inhibit Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophages via Suppression of NF-κB Signaling Pathway.

ABSTRACT: Limited information is available regarding the health-promoting activities of sweetpotato leaves (SPL). The present study investigated antioxidant and anti-inflammatory effects, and phenolic contents in 29 SPL cultivars harvested in 2018 and 2019. Extracts showed total phenolic contents 9.4-23.1 mg gallic acid equivalent/g, and DPPH radical scavenging activity indicated 36.6-247.3 mM of Trolox equivalent/g. SPL extracts were identified to contain bioactive components such as, chlorogenic acid (11.7-22.1 μg/mg), 3,4-dicaffeoylquinic acid (16.3-59.9 μg/mg), 3,5-dicaffeoylquinic acid (50.9-72.7 μg/mg), chlorophyll B (6.1-12.3 μg/mg), lutein (1.9-4.9 μg/mg), chlorophyll A (2.7-4.3 μg/mg) and β-carotene (0.1 ≤ μg/mg). RAW 264.7 murine macrophage cells were pretreated with 100-200 μg/mL of SPL e

SUBMITTER: Cho HD 

PROVIDER: S-EPMC8464942 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature