Targeting Toll-like Receptor (TLR) Pathways in Inflammatory Arthritis: Two Better Than One?

ABSTRACT: Inflammatory arthritis is a cluster of diseases caused by unregulated activity of the immune system. The lost homeostasis is followed by the immune attack of one's self, what damages healthy cells and tissues and leads to chronic inflammation of various tissues and organs (e.g., joints, lungs, heart, eyes). Different medications to control the excessive immune response are in use, however, drug resistances, flare-reactions and adverse effects to the current therapies are common in the affected patients. Thus, it is essential to broaden the spectrum of alternative treatments and to develop disease-modifying drugs. In the last 20 years, the involvement of the innate immune receptors TLRs in inflammatory arthritis has been widely investigated and targeting either the receptor itself or the pr

SUBMITTER: Santos-Sierra S 

PROVIDER: S-EPMC8464963 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature