Identification of Arvicola terrestris scherman Sperm Antigens for Immune Contraceptive Purposes.

ABSTRACT: The cyclical proliferation of the wild fossorial rodent Arvicola terrestris scherman (ATS) is critical in mid-mountain ecosystems of several European countries. Our goal is to develop an immunocontraceptive vaccine to control their fertility, as a sustainable alternative to chemical poisons currently used. Indeed, these chemicals cause the death of ATS predators and animals sharing their ecosystem, and current laws progressively limit their use, making the development of a targeted vaccination strategy an interesting and efficient alternative. In order to identify species-specific sperm antigens, male and female ATS received subcutaneous injections of whole ATS spermatozoa to elicit an immune response. The analysis of the immune sera led to the identifica

SUBMITTER: Chorfa A 

PROVIDER: S-EPMC8465135 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature