The Significance of VDR Genetic Polymorphisms in the Etiology of Preeclampsia in Pregnant Polish Women.

ABSTRACT: For the first time in the Polish population, we aimed to investigate associations between the VDR gene single-nucleotide polymorphisms (SNPs) BsmI (rs15444410), ApaI (rs7975232), FokI (rs19735810), and TaqI (rs731236) and the development of preeclampsia (PE). A case-control study surveyed 122 preeclamptic and 184 normotensive pregnant women. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was performed to examine the maternal VDR FokI, BsmI, TaqI, and ApaI polymorphisms. The VDR BsmIAA homozygous genotype was statistically significantly more frequent in preeclamptic women compared to the control group (p = 0.0263), which was also associated with a 2-fold increased ri

SUBMITTER: Magielda-Stola J 

PROVIDER: S-EPMC8465173 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature