Elucidating the Effects of Curcumin against Influenza Using In Silico and In Vitro Approaches.

ABSTRACT: The influenza virus is a constantly evolving pathogen that challenges medical and public health systems. Traditionally, curcumin has been used to treat airway inflammatory diseases, such as bronchitis and pneumonia. To elucidate common targets of curcumin and influenza infection and underlying mechanisms, we employed network pharmacology and molecular docking approaches and confirmed results using in vitro experiments. Biological targets of curcumin and influenza were collected, and potential targets were identified by constructing compound-disease target (C-D) and protein-protein interaction (PPI) networks. The ligand-target interaction was determined using the molecular docking method, and in vitro antiviral experiments and target confirmation were conducted to evaluate curcumin's effect

SUBMITTER: Kim M 

PROVIDER: S-EPMC8465221 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature