Peptide Characterization and Functional Stability of a Partially Hydrolyzed Whey-Based Formula over Time.

ABSTRACT: Human clinical trials have shown that a specific partially hydrolyzed 100% whey-based infant formula (pHF-W) reduces AD risk in the first yeast of life. Meta-analyses with a specific pHF-W (pHF-W1) confirm a protective effect while other meta-analyses pooling different pHF-W show conflicting results. Here we investigated the molecular composition and functional properties of the specific pHF-W1 as well as the stability of its manufacturing process over time. This specific pHF-W1 was compared with other pHF-Ws. We used size exclusion chromatography to characterize the peptide molecular weight (MW), a rat basophil degranulation assay to assess the relative level of beta-lactoglobulin (BLG) allergenicity and a preclinical model of oral tolerance induction to test prevention of allergic sensit

SUBMITTER: Bourdeau T 

PROVIDER: S-EPMC8465316 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature