Gut Hormones as Potential Therapeutic Targets or Biomarkers of Response in Depression: The Case of Motilin.

ABSTRACT: Recent research has identified the gut-brain axis as a key mechanistic pathway and potential therapeutic target in depression. In this paper, the potential role of gut hormones as potential treatments or predictors of response in depression is examined, with specific reference to the peptide hormone motilin. This possibility is explored through two methods: (1) a conceptual review of the possible links between motilin and depression, including evidence from animal and human research as well as clinical trials, based on a literature search of three scientific databases, and (2) an analysis of the relationship between a functional polymorphism (rs2281820) of the motilin (MLN) gene and cross-national variations in the prevalence of depression based on allele frequency data after correction fo

SUBMITTER: Rajkumar RP 

PROVIDER: S-EPMC8465535 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature