Neuroblastoma Cells Depend on CSB for Faithful Execution of Cytokinesis and Survival.

ABSTRACT: Neuroblastoma, the most common extra-cranial solid tumor of early childhood, is one of the major therapeutic challenges in child oncology: it is highly heterogenic at a genetic, biological, and clinical level. The high-risk cases have one of the least favorable outcomes amongst pediatric tumors, and the mortality rate is still high, regardless of the use of intensive multimodality therapies. Here, we observed that neuroblastoma cells display an increased expression of Cockayne Syndrome group B (CSB), a pleiotropic protein involved in multiple functions such as DNA repair, transcription, mitochondrial homeostasis, and cell division, and were recently found to confer cell robustness when they are up-regulated. In this study, we demonstrated that RNAi-mediated suppression of CSB drastically i

SUBMITTER: Paccosi E 

PROVIDER: S-EPMC8465547 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature