Small Molecules Targeting Programmed Cell Death in Breast Cancer Cells.

ABSTRACT: Targeted chemotherapy has become the forefront for cancer treatment in recent years. The selective and specific features allow more effective treatment with reduced side effects. Most targeted therapies, which include small molecules, act on specific molecular targets that are altered in tumour cells, mainly in cancers such as breast, lung, colorectal, lymphoma and leukaemia. With the recent exponential progress in drug development, programmed cell death, which includes apoptosis and autophagy, has become a promising therapeutic target. The research in identifying effective small molecules that target compensatory mechanisms in tumour cells alleviates the emergence of drug resistance. Due to the heterogenous nature of breast cancer, various attempts were made to overcome chemoresistance. A

SUBMITTER: Maniam S 

PROVIDER: S-EPMC8465612 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature