MiR-410-3P inhibits adipocyte differentiation by targeting IRS-1 in cancer-associated cachexia patients.

ABSTRACT:

Backgrounds

Cancer-associated cachexia (CAC) is a metabolic syndrome characterized by progressive depletion of adipose and muscle tissue that cannot be corrected by conventional nutritional therapy. Adipose tissue, an important form of energy storage, exhibits marked loss in the early stages of CAC, which affects quality of life and efficacy of chemotherapy. MicroRNAs (miRNAs) are a class of noncoding RNAs that widely exist in all kinds of eukaryotic cells and play regulatory roles in various biological processes. However, the role of miRNAs in adipose metabolism in CAC has rarely been reported. This study attempted to identify important miRNAs in adipose metabolism in CAC and explore their mechanism to identify a new predictive marker or therapeutic target for CAC-related adipose

SUBMITTER: Sun D 

PROVIDER: S-EPMC8465700 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature