Development of a Compartmental Pharmacokinetic Model for Molecular Radiotherapy with 131I-CLR1404.

ABSTRACT: Pharmacokinetic modeling of the radiopharmaceuticals used in molecular radiotherapy is an important step towards accurate radiation dosimetry of such therapies. In this paper, we present a pharmacokinetic model for CLR1404, a phospholipid ether analog that, labeled with 124I/131I, has emerged as a promising theranostic agent. We follow a systematic approach for the model construction based on a decoupling process applied to previously published experimental data, and using the goodness-of-fit, Sobol's sensitivity analysis, and the Akaike Information Criterion to construct the optimal form of the model, investigate potential simplifications, and study factor prioritization. This methodology was applied to previously published experimental human time-activity curves for 9 organs. The resulti

SUBMITTER: Neira S 

PROVIDER: S-EPMC8465706 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature