The PSC scientific community resource: an asset for multi-omics interrogation of primary sclerosing cholangitis.

ABSTRACT:

Background

Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease that often progresses to end-stage liver disease and/or the development of hepatobiliary neoplasia. Lack of prognostic tools and treatment options for PSC is driven in part by our poor understanding of its pathogenesis, which is thought to be complex, the interaction of genetic variants, environmental influences and biological response throughout the course of disease. The PSC Scientific Community Resource (PSC-SCR) seeks to overcome previous shortcomings by facilitating novel research in PSC with the ultimate goals of individualizing patient care and improving patient outcomes.

Methods

PSC patients who receive their health care at Mayo Clinic or a collaborating site are identified b

SUBMITTER: Ali AH 

PROVIDER: S-EPMC8465725 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature