Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives.

ABSTRACT: Changes in cell growth and metabolism are affected by the surrounding environmental factors to adapt to the cell's most appropriate growth model. However, abnormal cell metabolism is correlated with the occurrence of many diseases and is accompanied by changes in galectin (Gal) performance. Gals were found to be some of the master regulators of cell-cell interactions that reconstruct the microenvironment, and disordered expression of Gals is associated with multiple human metabolic-related diseases including cancer development. Cancer cells can interact with surrounding cells through Gals to create more suitable conditions that promote cancer cell aggressiveness. In this review, we organize the current understanding of Gals in a systematic way to dissect Gals' effect on human disease, incl

SUBMITTER: Li CH 

PROVIDER: S-EPMC8465754 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature