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Chemical Exchanges between Multilateral Symbionts.

ABSTRACT: Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis.

SUBMITTER: Bae M

PROVIDER: S-EPMC8465764 | biostudies-literature |

REPOSITORIES: biostudies-literature

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