Hepatocellular Carcinoma Outcome Is Predicted by Expression of Neuronal Calcium Sensor 1.

ABSTRACT: Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. There is an urgent demand for prognostic biomarkers that facilitate early tumor detection, as the incidence of HCC has tripled in the United States in the last three decades. Biomarkers to identify populations at risk would have significant impact on survival. We recently found that expression of Neuronal Calcium Sensor 1 (NCS1), a Ca2⁺-dependent signaling molecule, predicted disease outcome in breast cancer, but its predictive value in other cancer types is unknown. This protein is potentially useful because increased NCS1 regulates Ca2⁺ signaling and increased Ca2⁺ signaling is a hallmark of metastatic cancers, conferring cellular motility and

SUBMITTER: Schuette D 

PROVIDER: S-EPMC8465775 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature