D-Mannoside FimH Inhibitors as Non-Antibiotic Alternatives for Uropathogenic Escherichia coli.

ABSTRACT: FimH is a type I fimbria of uropathogenic Escherichia coli (UPEC), recognized for its ability to adhere and infect epithelial urinary tissue. Due to its role in the virulence of UPEC, several therapeutic strategies have focused on the study of FimH, including vaccines, mannosides, and molecules that inhibit their assembly. This work has focused on the ability of a set of monosubstituted and disubstituted phenyl mannosides to inhibit FimH. To determine the 3D structure of FimH for our in silico studies, we obtained fifteen sequences by PCR amplification of the fimH gene from 102 UPEC isolates. The fimH sequences in BLAST had a high homology (97-100%) to our UPEC fimH sequences. A search for the three-dimensional crystallographic structure of FimH proteins in the

SUBMITTER: Montes-Robledo A 

PROVIDER: S-EPMC8465801 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature