Cationic Liposomes as Vectors for Nucleic Acid and Hydrophobic Drug Therapeutics.

ABSTRACT: Cationic liposomes (CLs) are effective carriers of a variety of therapeutics. Their applications as vectors of nucleic acids (NAs), from long DNA and mRNA to short interfering RNA (siRNA), have been pursued for decades to realize the promise of gene therapy, with approvals of the siRNA therapeutic patisiran and two mRNA vaccines against COVID-19 as recent milestones. The long-term goal of developing optimized CL-based NA carriers for a broad range of medical applications requires a comprehensive understanding of the structure of these vectors and their interactions with cell membranes and components that lead to the release and activity of the NAs within the cell. Structure-activity relationships of lipids for CL-based NA and drug delivery must take into account that these lipids act not i

SUBMITTER: Ewert KK 

PROVIDER: S-EPMC8465808 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature