Goals and Challenges of Stem Cell-Based Therapy for Corneal Blindness Due to Limbal Deficiency.

ABSTRACT: Corneal failure is a highly prevalent cause of blindness. One special cause of corneal failure occurs due to malfunction or destruction of the limbal stem cell niche, upon which the superficial cornea depends for homeostatic maintenance and wound healing. Failure of the limbal niche is referred to as limbal stem cell deficiency. As the corneal epithelial stem cell niche is easily accessible, limbal stem cell-based therapy and regenerative medicine applied to the ocular surface are among the most highly advanced forms of this novel approach to disease therapy. However, the challenges are still great, including the development of cell-based products and understanding how they work in the patient's eye. Advances are being made at the molecular, cellular, and tissue levels to alter disease pro

SUBMITTER: Calonge M 

PROVIDER: S-EPMC8466237 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature