Targeted Nanoparticle Photodynamic Diagnosis and Therapy of Colorectal Cancer.

ABSTRACT: Colorectal cancer (CRC) is an aggressive cancer that remains a challenge to diagnose and treat. Photodynamic diagnosis (PDD) and therapy (PDT) are novel alternative techniques, which can enhance early diagnosis, as well as elicit tumor cell death. This is accomplished through photosensitizer (PS) mediated fluorescence and cytotoxic reactive oxygen species activation upon laser light irradiation excitation at specific low and high range wavelengths, respectively. However, the lack of PS target tumor tissue specificity often hampers these techniques. This study successfully fabricated a bioactive nanoconjugate, ZnPcS₄-AuNP-S-PEG5000-NH₂-Anti-GCC mAb (BNC), based upon a polyethylene glycol-gold nanoparticle, which was multi-functionalized with a fluorescent PDT metalated

SUBMITTER: Simelane NWN 

PROVIDER: S-EPMC8466279 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature