Transcriptomic Changes Following Partial Depletion of CENP-E in Normal Human Fibroblasts.

ABSTRACT: The centromere is a fundamental chromosome structure in which the macro-molecular kinetochore assembles and is bound by spindle microtubules, allowing the segregation of sister chromatids during mitosis. Any alterations in kinetochore assembly or functioning or kinetochore-microtubule attachments jeopardize chromosome stability, leading to aneuploidy, a common feature of cancer cells. The spindle assembly checkpoint (SAC) supervises this process, ensuring a faithful segregation of chromosomes. CENP-E is both a protein of the kinetochore and a crucial component of the SAC required for kinetochore-microtubule capture and stable attachment, as well as congression of chromosomes to the metaphase plate. As the function of CENP-E is restricted to mitosis, its haploinsufficiency has been used to

SUBMITTER: Cilluffo D 

PROVIDER: S-EPMC8466516 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature