Synchrotron-Based Fourier-Transform Infrared Micro-Spectroscopy (SR-FTIRM) Fingerprint of the Small Anionic Molecule Cobaltabis(dicarbollide) Uptake in Glioma Stem Cells.

ABSTRACT: The anionic cobaltabis (dicarbollide) [3,3'-Co(1,2-C₂B₉H₁₁)₂]^-, [o-COSAN]^-, is the most studied icosahedral metallacarborane. The sodium salts of [o-COSAN]^- could be an ideal candidate for the anti-cancer treatment Boron Neutron Capture Therapy (BNCT) as it possesses the ability to readily cross biological membranes thereby producing cell cycle arrest in cancer cells. BNCT is a cancer therapy based on the potential of ¹⁰B atoms to produce α particles that cross tissues in which the ¹⁰B is accumulated without damaging the surrounding healthy tissues, after being irradiated with low energy thermal neutrons. Since Na[o-COSAN] displays a strong and characteristic ν(B-H) frequ

SUBMITTER: Nuez-Martinez M 

PROVIDER: S-EPMC8466526 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature