Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD) is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-AD drugs. Recently, a therapeutic strategy based on the exploitation of Brazilian biodiversity was set with the aim of discovering new disease-modifying and safe drugs for AD. In this review, we will illustrate our efforts in developing new molecules derived from Brazilian cashew nut shell liquid (CNSL), a natural oil and a byproduct of cashew nut food processing, with a high content of phenolic lipids. The rational modification of their structures has emerged as a successful medicinal chemistry approach to the development of novel anti-AD lead candidates. The biological profile of the newly developed CNSL derivatives towards validat

SUBMITTER: Uliassi E 

PROVIDER: S-EPMC8466601 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature