Insights into Comparative Modeling of V_HH Domains.

ABSTRACT: In the particular case of the Camelidae family, immunoglobulin proteins have evolved into a unique and more simplified architecture with only heavy chains. The variable domains of these chains, named V_HHs, have a number of Complementary Determining Regions (CDRs) reduced by half, and can function as single domains making them good candidates for molecular tools. 3D structure prediction of these domains is a beneficial and advantageous step to advance their developability as molecular tools. Nonetheless, the conformations of CDRs loops in these domains remain difficult to predict due to their higher conformational diversity. In addition to CDRs loop diversity, our earlier study has established that Framework Regions (FRs) are also not entirely conformationally conserved wh

SUBMITTER: Vattekatte AM 

PROVIDER: S-EPMC8466624 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature