Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3.
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ABSTRACT:
SUBMITTER: Yuan Q
PROVIDER: S-EPMC8466683 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
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Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3.
Yuan Qianying Q Basit Abdul A Liang Wenhua W Qu Rihao R Luan Yi Y Ren Chunguang C Li Ao A Xu Xin X Liu Xiaoqing X Yang Chun C Kuo Andrew A Pierce Richard R Zhang Longbo L Turk Benjamin B Hu Xin X Li Fangyong F Cui Weixue W Li Run R Huang Danxia D Mo Lili L Sessa William C WC Lee Patty J PJ Kluger Yuval Y Su Bing B Tang Wenwen W He Jianxing J Wu Dianqing D
Science translational medicine 20210401 591
Acute lung injury (ALI) causes high mortality and lacks any pharmacological intervention. Here, we found that pazopanib ameliorated ALI manifestations and reduced mortality in mouse ALI models and reduced edema in human lung transplantation recipients. Pazopanib inhibits mitogen-activated protein kinase kinase kinase 2 (MAP3K2)- and MAP3K3-mediated phosphorylation of NADPH oxidase 2 subunit p47<sup>phox</sup> at Ser<sup>208</sup> to increase reactive oxygen species (ROS) formation in myeloid cel ...[more]
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