Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease.

ABSTRACT: Elevated levels of gut leakage markers have been shown after strenuous exercise in healthy individuals. Any association between a temporary increase in these markers and the presence of coronary artery disease (CAD) is unknown. We therefore aimed to explore circulating gut leakage markers in response to a bout of strenuous exercise in patients with symptoms of CAD. Patients referred to exercise stress testing due to symptoms of CAD were included (n = 287). A maximal exercise ECG stress test was performed and venous blood samples were drawn at rest and within five minutes after, for analysis of soluble cluster of differentiation 14 (sCD14), lipopolysaccharide-binding protein (LBP), intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide (LPS) and gene expression of toll-like rece

SUBMITTER: Aune SK 

PROVIDER: S-EPMC8466709 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature