Chromosome-Level Genome Assemblies Expand Capabilities of Genomics for Conservation Biology.

ABSTRACT: Genome assemblies are in the process of becoming an increasingly important tool for understanding genetic diversity in threatened species. Unfortunately, due to limited budgets typical for the area of conservation biology, genome assemblies of threatened species, when available, tend to be highly fragmented, represented by tens of thousands of scaffolds not assigned to chromosomal locations. The recent advent of high-throughput chromosome conformation capture (Hi-C) enables more contiguous assemblies containing scaffolds spanning the length of entire chromosomes for little additional cost. These inexpensive contiguous assemblies can be generated using Hi-C scaffolding of existing short-read draft assemblies, where N50 of the draft contigs is larger than 0.1% of the estimated genome size an

SUBMITTER: Totikov A 

PROVIDER: S-EPMC8466942 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature