The circadian rest-activity pattern predicts cognitive decline among mild-moderate Alzheimer's disease patients.

ABSTRACT:

Background

Alterations in circadian rhythms are present in the presymptomatic stage of Alzheimer's disease (AD), possibly contributing to its pathogenesis. However, it is unknown whether such alterations are associated with worse outcomes once individuals are diagnosed with symptomatic disease. We aimed to evaluate the association between the circadian rest-activity pattern and AD-related features in patients with mild-moderate AD.

Methods

We assessed the circadian rest-activity pattern of consecutive patients with mild-moderate AD through actigraphy for 14 days. Cerebrospinal fluid was obtained to determine the levels of important pathological markers including amyloid-beta protein (Aβ42), phosphorylated tau (P-tau), total tau (T-tau), and neurofilament light (NF-L). Neurop

SUBMITTER: Targa ADS 

PROVIDER: S-EPMC8466995 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature