Transcriptomics Underlying Pulmonary Ozone Pathogenesis Regulated by Inflammatory Mediators in Mice.

ABSTRACT: Ozone (O₃) is the predominant oxidant air pollutant associated with airway inflammation, lung dysfunction, and the worsening of preexisting respiratory diseases. We previously demonstrated the injurious roles of pulmonary immune receptors, tumor necrosis factor receptor (TNFR), and toll-like receptor 4, as well as a transcription factor NF-κB, in response to O₃ in mice. In the current study, we profiled time-dependent and TNFR- and NF-κB-regulated lung transcriptome changes by subacute O₃ to illuminate the underlying molecular events and downstream targets. Mice lacking Tnfr1/Tnfr2 (Tnfr^-/-) or Nfkb1 (Nfkb1^-/-) were exposed to air or O₃. Lung RNAs were prepared for cDNA microarray analyses,

SUBMITTER: Cho HY 

PROVIDER: S-EPMC8466999 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature