Walking around Ribosomal Small Subunit: A Possible "Tourist Map" for Electron Holes.

ABSTRACT: Despite several decades of research, the physics underlying translation-protein synthesis at the ribosome-remains poorly studied. For instance, the mechanism coordinating various events occurring in distant parts of the ribosome is unknown. Very recently, we suggested that this allosteric mechanism could be based on the transport of electric charges (electron holes) along RNA molecules and localization of these charges in the functionally important areas; this assumption was justified using tRNA as an example. In this study, we turn to the ribosome and show computationally that holes can also efficiently migrate within the whole ribosomal small subunit (SSU). The potential sites of charge localization in SSU are revealed, and it is shown that most of them are located in the functionally im

SUBMITTER: Sosorev AY 

PROVIDER: S-EPMC8467113 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature